Search all ALPCO products, resources, and website information

Responsibility
ALPCO’s Diabetes Research Travel GrantALPCO strives to provide scientists and healthcare professionals with robust tools for their research and clinical diagnostic endeavors. We understand that championing extraordinary discoveries requires extraordinary efforts, and support. We are proud to continu...
EOY Academic Discount
2023 Academic Discount* for Select Diabetes ELISA Kits ALPOC is excited to offer an exclusive, limited-time discount to academic institutions performing diabetes and obesity research. Catalog Number Description List Price 80-INSHU-CH01 Human Ins...
Advance your GLP-1 research with optimized assays
Advance your GLP-1 research with optimized assays  The growing interest in GLP-1 receptor agonists underscores their potential, not only in helping manage diabetes and obesity, but also in offering possible benefits for kidney and heart health.    We offer an extensive portfolio of immunoassays o...
About Us
About Magento Store Lorem ipsum dolor sit amet, consectetuer adipiscing elit. Morbi luctus. Duis lobortis. Nulla nec velit. Mauris pulvinar erat non massa. Suspendisse tortor turpis, porta nec, tempus vitae, iaculis semper, pede. Lorem ipsum dolor sit amet, consectetuer adipiscing elit. Mo...
Role of IGF-1 in the Growth Hormone/IGF Axis
The Growth Hormone/IGF axis consists of IGF-1, IGF-2 and several high and low affinity IGF Binding Proteins (IGFBP). The whole system is tightly regulated by a feedback loop involving Growth Hormone (GH) secreted by the pituitary, and GH production and secretion controlled by Growth Hormone Releasin...
Bone Metabolism: The Cycle of Bone Growth and Resorption
Bone metabolism is a continual cycle of bone growth and resorption that is carefully orchestrated by the dynamic relationship between osteoclasts, osteoblasts and an array of hormonal and regulatory influences. The relative levels of these signaling molecules dictate whether healthy, balanced bo...
Understanding the Role of Energy Homeostasis in Diabetes
Introduction The prevalence of diabetes and obesity has been on the rise for several decades and research has demonstrated that other parts of the body, including the cardiovascular system and kidneys, can be affected by diabetes. The key to understanding the relationship between diabetes and the...
Heart Disease Biomarkers in Diabetes Research
Introduction Cardiovascular disease (CVD) encompasses a constellation of diseases related to the heart and circulatory system. Despite efforts to understand and combat CVD complications from diabetes, 65% of diabetics will pass away from cardiovascular issues1. Part 2 of The Common Denominator eBoo...
Early Detection of Diabetic Kidney Disease with Biomarkers
Introduction Over one third of diabetics will develop diabetic kidney disease (DKD) in their lifetime1. Despite the large amount of diabetics suffering from DKD, current methods for measuring and tracking kidney function may not be specific enough for diabetic systems2,3. Part III of The Common ...
Customer Spotlight: Measuring Functionality of Islet Microtissues
Date: July 26, 2016 Beta cell generation has gained much traction in recent years among diabetes researchers. Investigators are not only converting adipose tissue and skin cells into beta cells, they are also starting to grow beta cells in a petri dish in vitro. Swiss company InSphero has begun m...
Choosing the Relevant GLP-1 Species to Study
  A better understanding of incretins has led to tremendous therapeutic advances in the field of type 2 diabetes1. These hormones are released from the gut in response to food ingestion and lead to the stimulation of pancreatic β-cells which then release insulin in a glucose-concentration de...
Emerging Biomarker Research in NAFLD and NASH
Nonalcoholic fatty liver disease (NAFLD) is becoming the most common chronic liver disease in the western hemisphere affecting 1 in 3 adults and 1 in 10 children1.  Today, liver biopsies are the only gold standard for precise diagnosis of NAFLD2. Because of this, there are tremendous efforts on the ...
ALPCO and InSphero Collaborate to Advance Metabolic Disease Research at ADA 2017
Date: June 6, 2017 ALPCO announced it will collaborate with InSphero, a supplier of 3D cell culture solutions, at the ADA’s 77th Scientific Sessions June 10-12 in San Diego. Together, ALPCO and InSphero aim to enhance the study of islet function, regeneration, and preservation by providing resear...
Adipokines and Adipose Tissue-Liver Crosstalk in Energy Metabolism
Research over the past several decades examining adipokines and adipose tissue-liver crosstalk in energy metabolism has revealed that adipose tissue is a very important metabolically active endocrine organ1. White, brown, and beige adipose tissue generate and secrete adipokines, such as adiponectin ...
Obesity Induced Adipose Tissue Dysfunction and NAFLD
Obesity is a known risk factor for developing metabolic diseases such as non-alcoholic fatty liver disease (NAFLD)1. An increasing amount of evidence shows that obesity induced adipose tissue dysfunction and NAFLD development are closely related2. Obesity induced changes to adipokine secretion can h...
Researching the Role of Gut Permeability in NAFLD
[playlist images="false" artists="false" tracklist="false" ids="4600"] A growing amount of research demonstrates that communication between the gut microbiota and liver is vital for the regulation of energy metabolism1,2. As a result, scientists are further...
Dorothy Hodgkin’s Discovery of Insulin's 3D Structure
Nobel Prize winning British chemist Dr. Dorothy Hodgkin significantly contributed to unraveling the secrets of diabetes mellitus. She is considered a founder of X-ray crystallography, a technique used to discern the structures of organic biomolecules. Dorothy Hodgkin’s discovery of insulin's 3D...
Organ Crosstalk in Obesity and NAFLD
The liver is vital to various metabolic functions including lipid and glucose metabolism. In order to maintain homeostasis, efficient gut-liver and adipose tissue-liver communications are needed1,2. Research indicates that obesity induced dysfunctions within these crosstalks can lead to imbalances i...
ALPCO and InSphero Partner to Offer a Complete Solution to Assess Beta-cell Function in Islet Microtissue Culture Models
July 23, 2018 ALPCO recently announced its partnership with InSphero, AG to provide customers with a complete solution to assess beta-cell function in islet microtissue culture models. InSphero’s 3D InSight™ Diabetes Discovery Platform offers users a comprehensive beta-cell function applic...
An Accurate Solution to the Challenges with Measuring GLP-1
Glucagon-like peptide-1 (GLP-1) is a gut hormone which plays an essential role in insulin secretion and glucose homeostasis1. While GLP-1 has become central to many metabolic disease research programs, various GLP-1 ELISA kits currently available on the market have been failing to meet the needs of ...
The Impact of DPP-4 on Active GLP-1 Preanalytical Variability
Active glucagon-like peptide-1 (active GLP-1) is an incretin hormone known for its pivotal role in the regulation of insulin and glucagon secretion1,2. However, research has demonstrated that the accurate quantification of active GLP-1 is difficult to achieve and has led to the widespread inability ...
The Generation and Function of Active GLP-1
The Generation and Function of Active GLP-1 Active glucagon-like peptide-1 (GLP-1) is a member of the incretin hormone family and is generated as a result of post translational modifications during proglucagon processing1,2. Active GLP-1 plays a key role in the incretin effect and is vital for main...
The Relationship Between Glucagon and Energy Homeostasis
Glucagon is a gut hormone generated as a result of post translational modifications during proglucagon processing in the pancreas1,2,3. Research has demonstrated that glucagon has many physiological functions1,4. Understanding the role of glucagon in energy homeostasis has become important to many d...
ALPCO Announces its January 2019 Diabetes Research Travel Grant Recipient
February 5, 2019 ALPCO announced the latest recipient of its Young Investigator Award, the Diabetes Travel Grant. The grant was created to help advance progressive diabetes and obesity research by graduate students, postdoctoral fellows, and early stage investigators. The program seeks to stimula...