The STELLUX® Chemi Active GLP-1 (7-36) amide ELISA is intended for the quantitative determination of active GLP- 1 (7-36) amide in human, mouse, and rat EDTA plasma samples collected in the presence of DPP-4 inhibitor.
Sample Volume: 25 µL
Analytical Sensitivity: 0.15 pM
Functional Sensitivity: 0.45 pM
Specificity: 100% for GLP-1 (7-36 amide); Non-detect for other forms
Research Use Only. Not for Use in Diagnostic Procedures.
Research Use Only. Not for Use in Diagnostic Procedures.
Product Distribution
Available Worldwide
Range
0.45 - 151.6 pM (1.5 - 500 pg/mL)
Sensitivity
0.15 pM (0.49 pg/mL)
Sizes
96 Wells
Sample Types
EDTA Plasma
Inc Time Hour
2
Inc Time Minute
52
Inc Time Overnight
No
Inc Time See Protocol
No
Sample Size
25
Detection
Chemiluminescence
Glucagon-like peptide-1 (GLP-1) is an extensively well-characterized incretin hormone which regulates both insulin and glucagon secretion. GLP-1 is a highly sought after therapeutic target due to its beneficial effects on glucose homeostasis, particularly through regulation of beta cell mass, function, and viability. GLP-1 is produced in intestinal L-cells in response to food and is well conserved across species. GLP-1 is derived from the cleavage of proglucagon to generate a 1-37 amino acid peptide. Fasting reduces circulating levels of GLP-1. GLP-1 has many physiological effects on the body. Diabetes and obesity scientists have been using two main GLP-1 research approaches: DPP-4 inhibition and GLP-1 analogs. DPP-4 can inactivate GLP-1 to its forms of GLP-1 (9-36 amide) and GLP-1 (9-37). By inhibiting DPP-4, scientists hope that GLP-1 can continue to influence insulin secretion and restore balance to energy homeostasis. The goal of developing GLP-1 analogs is to engineer a better GLP-1 molecule that has a longer half-life, thus providing longer influences over insulin secretion.
ALPCO’s Active GLP-1 (7-36) amide Chemiluminescence ELISA accurately measures the major biologically active circulating form of GLP-1.1,2 This well-characterized assay provides high analytical sensitivity, a short incubation time, and measures active GLP-1 (7-36) amide in fasted and fed samples.
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