We know that the proper collection and handling of samples is vital for eliminating analytical variability and improving accuracy when measuring active GLP-1 (7-36) amide. ALPCO is here to help your lab reduce technical errors and improve assay results when running the STELLUX® Chemi Active GLP-1 (7-36) amide ELISA. Watch our video series to learn how DPP-4 complicates measuring GLP-1 acc...

Glucagon is a gut hormone generated as a result of post translational modifications during proglucagon processing in the pancreas1,2,3. Research has demonstrated that glucagon has many physiological functions1,4. Understanding the role of glucagon in energy homeostasis has become important to many diabetes and obesity researchers5. However, researching the relationship between glucagon and ener...

The Generation and Function of Active GLP-1 Active glucagon-like peptide-1 (GLP-1) is a member of the incretin hormone family and is generated as a result of post translational modifications during proglucagon processing1,2. Active GLP-1 plays a key role in the incretin effect and is vital for maintaining glucose homeostasis1,2. As such, both the generation and function of active GLP-1 have be...

Active glucagon-like peptide-1 (active GLP-1) is an incretin hormone known for its pivotal role in the regulation of insulin and glucagon secretion1,2. However, research has demonstrated that the accurate quantification of active GLP-1 is difficult to achieve and has led to the widespread inability to compare data across studies3,4,5. It has been determined that the DPP-4 mediated degradation o...

Glucagon-like peptide-1 (GLP-1) is a gut hormone which plays an essential role in insulin secretion and glucose homeostasis1. While GLP-1 has become central to many metabolic disease research programs, various GLP-1 ELISA kits currently available on the market have been failing to meet the needs of researchers1-5. Therefore, measuring total and active levels of GLP-1 is difficult for many labs2...

Watch our video to learn more about the STELLUX® Chemi Active GLP-1 (7-36) amide ELISA and how you can now measure this incretin hormone with confidence. https://www.youtube.com/watch?v=Chu3VhEEpt0&t=3s The STELLUX® Chemi Active GLP-1 (7-36) amide ELISA features increased sensitivity to accurately quantify active GLP-1 (7-36) amide levels as low as 1.5 pg/mL with a 25 µL sample volume...

The liver is vital to various metabolic functions including lipid and glucose metabolism. In order to maintain homeostasis, efficient gut-liver and adipose tissue-liver communications are needed1,2. Research indicates that obesity induced dysfunctions within these crosstalks can lead to imbalances in energy metabolism and contribute to the pathogenesis of metabolic diseases such as nonalcoholic...

Nobel Prize winning British chemist Dr. Dorothy Hodgkin significantly contributed to unraveling the secrets of diabetes mellitus. She is considered a founder of X-ray crystallography, a technique used to discern the structures of organic biomolecules. Dorothy Hodgkin’s discovery of insulin's 3D structure paved the way for many scientific breakthroughs in diabetes research for years to follow. I...

[playlist images="false" artists="false" tracklist="false" ids="4600"] A growing amount of research demonstrates that communication between the gut microbiota and liver is vital for the regulation of energy metabolism1,2. As a result, scientists are further exploring the relationship between the gut microbiota and gut-liver crosstalk to better understand metabolic diseases such as non-alcoho...

Research over the past several decades examining adipokines and adipose tissue-liver crosstalk in energy metabolism has revealed that adipose tissue is a very important metabolically active endocrine organ1. White, brown, and beige adipose tissue generate and secrete adipokines, such as adiponectin and leptin, which facilitate adipose tissue-liver crosstalk and insulin sensitivity1. https://...