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800 million people worldwide struggle with obesity, a disease which will cost over $1 trillion in medical consequences by 2025. The CDC reports that severe obesity leads to life-altering and often life-threatening conditions like heart disease, stroke, type 2 diabetes, and certain cancers.
What is the “Incretin Effect”?
To help understand the mechanisms behind obesity and to develop trea...
Introduction
The prevalence of diabetes and obesity has been on the rise for several decades and research has demonstrated that other parts of the body, including the cardiovascular system and kidneys, can be affected by diabetes. The key to understanding the relationship between diabetes and these other areas begins with the role of energy homeostasis in diabetes. At the same time, investig...
Melatonin is an endogenously expressed hormone present in a wide spectrum of organisms from bacteria to humans. Primarily secreted by the pineal gland, melatonin enters the circulation via cerebrospinal fluid and plays a key role in the regulation of the sleep-wake cycle. Melatonin levels help modulate mood, reproduction, and immune system activities. The rise and fall of circulating level...
The Diabetes Pandemic
According to the U.S. Centers for Disease Control (CDC) and the World Health Organization, more than 34 million Americans and 422 million people worldwide have diabetes.1,2 90 to 95% of people with diabetes have type 2.1 The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) estimates that more than 1 in 3 U.S. adults (~84 million) have prediabetes...
Pancreatic Islets of Langerhans function as a micro-organ with tightly coordinated hormone signaling between the different cell types. Understanding the network of islet cells is important in the fight against diabetes because of their relationship with glucose homeostasis.
Download our research review to learn about:
The five types of pancreatic islet cells
Pancreatic islet hormone bi...
Today, multiple immunoassay platforms exist, providing scientists and clinicians with the means to measure a variety of biomarkers1,2,3. However, research indicates some immunoassay platforms have limitations that can inhibit progress in the laboratory4,5,6. In an effort to provide researchers with a tool to overcome some of these limitations, ALPCO developed its STELLUX® chemiluminescence immu...
We know that the proper collection and handling of samples is vital for accurately measuring GLP-1.
ALPCO is here to help your lab reduce technical errors and improve assay results when running the STELLUX® Chemi Active GLP-1 (7-36) amide ELISA.
Watch our video to learn how to properly collect and handle GLP-1 samples for more accurate results.
https://youtu.be/j6_YgA2NCO8
Video Trans...
We know that the proper collection and handling of samples is vital for eliminating analytical variability and improving accuracy when measuring active GLP-1 (7-36) amide.
ALPCO is here to help your lab reduce technical errors and improve assay results when running the STELLUX® Chemi Active GLP-1 (7-36) amide ELISA.
Watch our video series to learn how DPP-4 complicates measuring GLP-1 acc...
Glucagon is a gut hormone generated as a result of post translational modifications during proglucagon processing in the pancreas1,2,3. Research has demonstrated that glucagon has many physiological functions1,4. Understanding the role of glucagon in energy homeostasis has become important to many diabetes and obesity researchers5. However, researching the relationship between glucagon and ener...
