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800 million people worldwide struggle with obesity, a disease poised to cost over $1 trillion in medical consequences by 2025. Over 40% of the US population is impacted, according to the Centers for Disease Control. Obesity is a major risk factor in the development of illnesses that lead to diabetes, such as insulin resistance, hypertension, and other metabolic disorders. Long-term disrupti...
Introduction
The prevalence of diabetes and obesity has been on the rise for several decades and research has demonstrated that other parts of the body, including the cardiovascular system and kidneys, can be affected by diabetes. The key to understanding the relationship between diabetes and these other areas begins with the role of energy homeostasis in diabetes. At the same time, investig...
Iron Homeostasis
Iron is a trace element required for several critical cellular processes. Too little iron (anemia) or too much iron (iron overload) can be harmful. While there is no known mechanism for the controlled excretion of excess iron, a handful of regulatory proteins control the absorption, transport, and storage of iron to maintain homeostasis.1,2 ALPCO offers several kits for the ...
Melatonin is an endogenously expressed hormone present in a wide spectrum of organisms from bacteria to humans. Primarily secreted by the pineal gland, melatonin enters the circulation via cerebrospinal fluid and plays a key role in the regulation of the sleep-wake cycle. Melatonin levels help modulate mood, reproduction, and immune system activities. The rise and fall of circulating level...
Glucagon-like peptide-1 (GLP-1) is a gut hormone which plays an essential role in insulin secretion and glucose homeostasis1. While GLP-1 has become central to many metabolic disease research programs, various GLP-1 ELISA kits currently available on the market have been failing to meet the needs of researchers1-5. Therefore, measuring total and active levels of GLP-1 is difficult for many labs2...
Introduction
Humans and the environment are exposed to numerous chemicals every day1. Each year, about 2,000 new chemicals are manufactured in the U.S.2. Research findings over the years have shown how some chemicals known as endocrine disrupting chemicals (EDCs) can interact with the endocrine system, disrupt homeostasis, and lead to issues such as obesity and sterility1. As a result, endocri...
Date: September 27, 2016
Author: Andrea Tarbet, Product Marketing Associate at ALPCO
From cosmetics to water bottles, endocrine disrupting chemicals (EDCs) have surfaced in our everyday lives. EDCs are compounds that can interfere with the endocrine system’s ability to help an organism develop, grow, reproduce, and maintain overall homeostasis1. Since EDCs are found nearly everywhere, we...
ALPCO is now offering a new broad range Periostin ELISA that has been optimized to detect all known splicing forms of human periostin. The Periostin ELISA is highly characterized with a full validation package, and offers great reproducibility and precision. Not only are all standards and controls included with the kit, but it can be automated, making the assay both cost effective and flexible ...
As a runner, I’ve long been intrigued by what gets me high during my runs. Endorphins, you say? Yes, I’m well aware of those and bless those endorphins. But, I have to say, there’s nothing quite as satiating as a good run and as a scientist by training, I was convinced that there was more to that feeling than endorphins. Turns out, there is.
It wasn’t too long ago that I came acros...
