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BTK Inhibitors as Cancer Drug Treatments
Date: July 26, 2016 Author: Andrea Tarbet, Product Marketing Associate at ALPCO Over the past several years, the drug arsenal to combat B cell cancers has gained a mighty weapon: Bruton’s tyrosine kinase (BTK) inhibitors. The origins of using BTK inhibitors as cancer drug treatments actually b...
Class IA PI3K Inhibitor Cancer Therapies
Date: August 16, 2016 Author: Andrea Tarbet, Product Marketing Associate at ALPCO Bruton’s tyrosine kinase (BTK) inhibitors are not the only kinase inhibitors to enter the fight against B cell cancers. Since there are numerous subtypes of Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL), p...
Role of IGF-1 in the Growth Hormone/IGF Axis
The Growth Hormone/IGF axis consists of IGF-1, IGF-2 and several high and low affinity IGF Binding Proteins (IGFBP). The whole system is tightly regulated by a feedback loop involving Growth Hormone (GH) secreted by the pituitary, and GH production and secretion controlled by Growth Hormone Releasin...
Bone Metabolism: The Cycle of Bone Growth and Resorption
Bone metabolism is a continual cycle of bone growth and resorption that is carefully orchestrated by the dynamic relationship between osteoclasts, osteoblasts and an array of hormonal and regulatory influences. The relative levels of these signaling molecules dictate whether healthy, balanced bo...
How Should We Define Vitamin D Deficiency?
Date: July 21, 2015 Author: Bethany Bell, PhD; Senior Product Manager at ALPCO Dr. Anders Berg presented at the Northeast Laboratory Conference in October 2014 regarding a much debated topic: vitamin D deficiency and how this should be defined. Dr. Berg referenced over one thousand studies, re...
CisBio's Chromoa® Chromogranin A ELISA
Chromoa® The Chromoa® Chromogranin A ELISA from Cisbio Bioassays is for the quantitative determination of CgA in serum and plasma. The patented monoclonal detection system provides superior specificity, sensitivity and reproducibility to determine elevated serum CgA levels. Above all, the hook effe...
ALPCO and Cisbio US, Inc. Announce Sales and Distribution Agreement
Date: July 1, 2015 ALPCO is pleased to announce a strategic account sales and distribution agreement with Cisbio US, Inc. Cisbio will now have exclusive access to ALPCO’s high quality STELLUX® Chemiluminescence and colorimetric Diabetes and Obesity assay portfolio in order to provide these produc...
Simplify Stool Sample Processing
Introduction We understand the challenges facing lab managers and directors who need to continuously improve workflow efficiency and implement new tests and technologies to be competitive. Our unique extraction method can be used with a portfolio of targeted stool markers. This allows your lab to s...
New Stool-Based Gastroenterology Assays and Extraction Method Can Improve Lab Sample Processing Time By Up To 86%
Date: January 26, 2016 ALPCO recently launched a new panel of 13 stool-based gastroenterology assays that are all compatible with one single extraction step. The unique extraction method allows laboratories to improve their sample processing time by up to 86% by extracting one sample for up to 13...
Measuring Pancreatic Elastase to Diagnose Pancreatic Disease
Many digestive system disorders and diseases can  present similar types of symptoms including bloating, diarrhea, constipation, and weight gain/loss. In an effort to rule in or rule out the presence of one disease or the absence of another, clinicians will often turn to clinically approved stool-bas...
The Changing Roles of Bone Remodeling Biomarkers
Introduction Bones are traditionally known for their support, protection and movement properties, as well as their role in the processes of mineral balance and blood cell production. Research supports that bones do more than they were originally recognized for. Previous research investigating osteo...
PI3K Delta Signaling in Rheumatoid Arthritis
Date: September 6, 2016 Author: Andrea Tarbet, Product Marketing Associate at ALPCO Signaling pathways dictate the differentiation, activation, and functions of immune cells.  Even the slightest problem in one cell signaling pathway can transform the immune system and turn it against the body,...
Regulating Endocrine Disrupting Chemicals in Consumer Products
Date: September 27, 2016 Author: Andrea Tarbet, Product Marketing Associate at ALPCO From cosmetics to water bottles, endocrine disrupting chemicals (EDCs) have surfaced in our everyday lives. EDCs are compounds that can interfere with the endocrine system’s ability to help an organism develop...
[Infographic] Alternative NAFLD and NASH Screening Methods
Download our infographic to understand the prevalence of NAFLD and NASH, as well as how biomarkers can serve as alternative NAFLD and NASH screening methods.   Download Now Estimated Global Prevalence of NAFLD Research confirms that nonalcoholic fatty liver disease (NAFLD) has an es...
Emerging Biomarker Research in NAFLD and NASH
Nonalcoholic fatty liver disease (NAFLD) is becoming the most common chronic liver disease in the western hemisphere affecting 1 in 3 adults and 1 in 10 children1.  Today, liver biopsies are the only gold standard for precise diagnosis of NAFLD2. Because of this, there are tremendous efforts on the ...
Incretins GIP and GLP-1 in Diabetes and Obesity
800 million people worldwide struggle with obesity, a disease which will cost over $1 trillion in medical consequences by 2025.  The CDC reports that severe obesity leads to life-altering and often life-threatening conditions like heart disease, stroke, type 2 diabetes, and certain cancers. Wha...
Webinar On Demand: Multiplex IgE Testing and Molecular Allergens
Our speaker from MacroArray Diagnostics, Christian Harwanegg, PhD, discusses Multiplex IgE Testing and Molecular Allergens. Watch Now The ALEX2 ALLERGY XPLORER multiplex IgE panel enables screening of up to 300 environmental and food allergens with just 100 – 200µL of sample. Testing a lar...
Featured Biomarkers from A to Z
This handout briefly describes the role of several important hormones measured in research.
Diagnostic Testing in GI Health
 60 to 70 million Americans are affected by gastrointestinal (GI) diseases and disorders each year. The estimated annual U.S. cost associated with GI disorders is over 140 billion dollars. Gl diseases and disorders can have a significant impact on quality of life, often contributing to anxiety ...
Understanding Exocrine Pancreatic Insufficiency
Pancreatic Elastase (PE) Testing for Determination of Exocrine Pancreatic Insufficiency (EPI) Advantages of ALPCO PE Testing for Determination of EPI • No interference from PERT • Single sample collection without dietary restriction • Detection of both CELA3A and CELA3B isoforms • Compatibi...

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