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ALPCO specialists are leveraging their extensive expertise to create a growing collection of resources for your research and testing. Find resources that benefit your work using the handy filters.
What are IBD and IBS?
Inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) are two different gastrointestinal tract issues affecting millions of people every day. Although there is some overlap between symptoms of IBD and IBS, differences still remain in regards to pathologies, risks of developing related complications, and treatment options. Therefore, it is vital to properly d...
Introduction
Humans have at least 50 discovered hormones managing vital biological functions in the body. These hormones are produced by the body’s organs and glands. Natriuretic peptides (NPs) are structurally related hormones synthesized and released from the heart, including atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP). Due to some of the physiological actions of nat...
Introduction
Cardiovascular disease (CVD) encompasses a constellation of diseases related to the heart and circulatory system. Despite efforts to understand and combat CVD complications from diabetes, 65% of diabetics will pass away from cardiovascular issues1. Part 2 of The Common Denominator eBook series examines the relationship between diabetes and cardiovascular disease, and how investiga...
Date: January 26, 2016
ALPCO recently launched a new panel of 13 stool-based gastroenterology assays that are all compatible with one single extraction step. The unique extraction method allows laboratories to improve their sample processing time by up to 86% by extracting one sample for up to 13 biomarkers. In addition, each of these assays is flexible and can be run manually or on automate...
Introduction
We understand the challenges facing lab managers and directors who need to continuously improve workflow efficiency and implement new tests and technologies to be competitive. Our unique extraction method can be used with a portfolio of targeted stool markers. This allows your lab to simplify stool sample processing time by up to 86% by extracting one sample for up to 13 stool-bas...
Chromoa®
The Chromoa® Chromogranin A ELISA from Cisbio Bioassays is for the quantitative determination of CgA in serum and plasma. The patented monoclonal detection system provides superior specificity, sensitivity and reproducibility to determine elevated serum CgA levels. Above all, the hook effect that is typically seen in other CgA assays is not present, thereby providing you with confiden...
Drug-Induced Organ Injury
Toxicological side effects are a common obstacle in drug development pipelines and often manifest in site-specific damage to vital organs, including the liver, kidney and heart. Estimates of compound attrition from failure to meet safety endpoints are as high as 45% in preclinical models and 40% for Phase I clinical trials.1
Now more than ever, labs engaged in comp...
Bone metabolism is a continual cycle of bone growth and resorption that is carefully orchestrated by the dynamic relationship between osteoclasts, osteoblasts and an array of hormonal and regulatory influences. The relative levels of these signaling molecules dictate whether healthy, balanced bone metabolism ensues. Disturbances to this delicate equilibrium where resorption is greater than ...
Understanding Vitamin D Metabolism & Function
Vitamin D is a steroid hormone involved in the intestinal absorption of calcium and the regulation of calcium homeostasis, bone differentiation and immune response. The term "vitamin D" refers to several different forms of this vitamin.
There are two major types of vitamin D:
Vitamin D2 (ergocalciferol) – which is synthesized by plants ...
The Growth Hormone/IGF axis consists of IGF-1, IGF-2 and several high and low affinity IGF Binding Proteins (IGFBP). The whole system is tightly regulated by a feedback loop involving Growth Hormone (GH) secreted by the pituitary, and GH production and secretion controlled by Growth Hormone Releasing Hormone (GHRH) at the hypothalamus.
Insulin-like Growth Factors & Binding Pr...
