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Date: August 16, 2016
Author: Andrea Tarbet, Product Marketing Associate at ALPCO
Bruton’s tyrosine kinase (BTK) inhibitors are not the only kinase inhibitors to enter the fight against B cell cancers. Since there are numerous subtypes of Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL), patients around the world are in need of diverse treatments and cures. As a result, different type...
Date: July 26, 2016
Beta cell generation has gained much traction in recent years among diabetes researchers. Investigators are not only converting adipose tissue and skin cells into beta cells, they are also starting to grow beta cells in a petri dish in vitro. Swiss company InSphero has begun measuring functionality of islet microtissues through the use of STELLUX® Chemiluminescent assays....
Date: July 26, 2016
Author: Andrea Tarbet, Product Marketing Associate at ALPCO
Over the past several years, the drug arsenal to combat B cell cancers has gained a mighty weapon: Bruton’s tyrosine kinase (BTK) inhibitors. The origins of using BTK inhibitors as cancer drug treatments actually began with researching drug treatments for an autoimmune disease. Two decades later, the first BTK...
Date: June 21, 2016
Author: Andrea Tarbet, Product Marketing Associate at ALPCO
Several therapies exist to help treat inflammatory bowel disease (IBD) and improve patient quality of life. However, a growing number of gastroenterologists and patients have been choosing to stop these therapies - a process known as de-escalation. There is currently no standard of care for de-escalating infla...
Introduction
Bones are traditionally known for their support, protection and movement properties, as well as their role in the processes of mineral balance and blood cell production. Research supports that bones do more than they were originally recognized for. Previous research investigating osteocalcin not only helped to change the scientific community’s understanding of bones, but also incr...
ALPCO is now offering a new broad range Periostin ELISA that has been optimized to detect all known splicing forms of human periostin. The Periostin ELISA is highly characterized with a full validation package, and offers great reproducibility and precision. Not only are all standards and controls included with the kit, but it can be automated, making the assay both cost effective and flexible ...
May 3, 2016
Leptin resistance is a challenging topic of conversation in obesity. It is defined by a state in which the body does not display any adapted response to high endogenous or exogenous levels of leptin while continuing to maintain excess body weight1. This may be due to a decreased uptake of leptin in the brain, reduced central response to leptin, or hypothalamic inflammation1. Cong...
The Biology of Leptin
Leptin is a hormone composed of 167 amino acids and is primarily produced by adipocytes, therefore providing a signal to the energy state of organisms. By binding to the leptin receptor, the analyte influences activity within the JAK-STAT pathway and thereby regulates energy metabolism and food intake in particular1,2. Leptin levels show a circadian variation (+/- 30%) an...
Introduction
Over one third of diabetics will develop diabetic kidney disease (DKD) in their lifetime1. Despite the large amount of diabetics suffering from DKD, current methods for measuring and tracking kidney function may not be specific enough for diabetic systems2,3.
Part III of The Common Denominator eBook series examines the kidney complications caused by diabetes, and current resear...
As a runner, I’ve long been intrigued by what gets me high during my runs. Endorphins, you say? Yes, I’m well aware of those and bless those endorphins. But, I have to say, there’s nothing quite as satiating as a good run and as a scientist by training, I was convinced that there was more to that feeling than endorphins. Turns out, there is.
It wasn’t too long ago that I came acros...
