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Drug-Induced Organ Injury
Toxicological side effects are a common obstacle in drug development pipelines and often manifest in site-specific damage to vital organs, including the liver, kidney and heart. Estimates of compound attrition from failure to meet safety endpoints are as high as 45% in preclinical models and 40% for Phase I clinical trials.1
Now more than ever, labs engaged in comp...
Understanding Vitamin D Metabolism & Function
Vitamin D is a steroid hormone involved in the intestinal absorption of calcium and the regulation of calcium homeostasis, bone differentiation and immune response. The term "vitamin D" refers to several different forms of this vitamin.
There are two major types of vitamin D:
Vitamin D2 (ergocalciferol) – which is synthesized by plants ...
