Organ Crosstalk in Obesity and NAFLD eBook

A thumbnail preview of the ebook Organ Crosstalk in Obesity and NAFLD.

The liver is vital to various metabolic functions including lipid and glucose metabolism. In order to maintain homeostasis, efficient gut-liver and adipose tissue-liver communications are needed1,2.

Research indicates that obesity induced dysfunctions within these crosstalks can lead to imbalances in energy metabolism and contribute to the pathogenesis of metabolic diseases such as nonalcoholic fatty liver disease (NAFLD)1,3.

As the global prevalence of NAFLD continues to rise, researchers are working towards understanding how mechanisms behind liver-organ crosstalk and energy homeostasis can influence metabolic diseases1,4,5.


  1. Kirpich et al. (2015). Gut-liver axis, nutrition, and non-alcoholic fatty liver disease. Clin Biochem. 2015 Sep;48(13-14):923-30. PMID: 26151226.
  2. Combs & Marliss. (2014). Adiponectin signaling in the liver. Rev Endocr Metab Disord. 2014 Jun;15(2):137-47. PMID: 24297186.
  3. Kitade et al. (2017). Nonalcoholic fatty liver disease and insulin resistance: New insights and potential new treatments. Nutrients. 2017 Apr;9(4): 387. PMCID: PMC540972.
  4. Townsend & Newsome. (2016). Non-alcoholic fatty liver disease in 2016. Br Med Bull. 2016 Sep;119(1):143-56. PMID: 27543499.
  5. Rui. (2014). Energy metabolism in the liver. ComprPhysiol. 2014 Jan; 4(1):177–197. PMCID: PMC4050641.