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ALPCO’s Diabetes Research Travel GrantALPCO strives to provide scientists and healthcare professionals with robust tools for their research and clinical diagnostic endeavors. We understand that championing extraordinary discoveries requires extraordinary efforts, and support. We are proud to continu...
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Explore ALPCO's Diverse Products for Gastroenterology Research
Explore ALPCO's Diverse Products for Gastroenterology Research
AGA Guidelines: Calprotectin and C-Reactive Protein Monitoring for the Management of Crohn’s Disease
Download our infograhpic prepared by ALPCO and gain a comprehensive overview of the American Gastroenterological Association ...
Featured Biomarkers from A to Z
This handout briefly describes the role of several important hormones measured in research.
Role of IGF-1 in the Growth Hormone/IGF Axis
The Growth Hormone/IGF axis consists of IGF-1, IGF-2 and several high and low affinity IGF Binding Proteins (IGFBP). The whole system is tightly regulated by a feedback loop involving Growth Hormone (GH) secreted by the pituitary, and GH production and secretion controlled by Growth Hormone Releasin...
Investigating Bioactive Leptin in Obesity Research
The Biology of Leptin
Leptin is a hormone composed of 167 amino acids and is primarily produced by adipocytes, therefore providing a signal to the energy state of organisms. By binding to the leptin receptor, the analyte influences activity within the JAK-STAT pathway and thereby regulates energy m...
BTK Inhibitors as Cancer Drug Treatments
Date: July 26, 2016
Author: Andrea Tarbet, Product Marketing Associate at ALPCO
Over the past several years, the drug arsenal to combat B cell cancers has gained a mighty weapon: Bruton’s tyrosine kinase (BTK) inhibitors. The origins of using BTK inhibitors as cancer drug treatments actually b...
Choosing the Relevant GLP-1 Species to Study
A better understanding of incretins has led to tremendous therapeutic advances in the field of type 2 diabetes1. These hormones are released from the gut in response to food ingestion and lead to the stimulation of pancreatic β-cells which then release insulin in a glucose-concentration de...
Obesity Induced Adipose Tissue Dysfunction and NAFLD
Obesity is a known risk factor for developing metabolic diseases such as non-alcoholic fatty liver disease (NAFLD)1. An increasing amount of evidence shows that obesity induced adipose tissue dysfunction and NAFLD development are closely related2. Obesity induced changes to adipokine secretion can h...
The Relationship Between Glucagon and Energy Homeostasis
Glucagon is a gut hormone generated as a result of post translational modifications during proglucagon processing in the pancreas1,2,3. Research has demonstrated that glucagon has many physiological functions1,4. Understanding the role of glucagon in energy homeostasis has become important to many d...
Celebrating Diabetes Research
In honor of scientists and researchers in the field of diabetes, we've compiled a partial list of their 2023 published work. These publications aren't just studies; they're milestones on the path to a healthier future, made possible by their dedication.
What makes this list so ...
Differentiating Gastrointestinal Pathogens from IBD and IBS
Gastrointestinal (GI) disorders such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), as well as infections from GI pathogens can present very similar symptoms. A host of tests have been developed to aid in the differentiation between IBD and IBS, such as calprotectin and lact...
Vitamin D Metabolism and Function
Understanding Vitamin D Metabolism & Function
Vitamin D is a steroid hormone involved in the intestinal absorption of calcium and the regulation of calcium homeostasis, bone differentiation and immune response. The term "vitamin D" refers to several different forms of this vitamin.
...
Toxicology
Drug-Induced Organ Injury
Toxicological side effects are a common obstacle in drug development pipelines and often manifest in site-specific damage to vital organs, including the liver, kidney and heart. Estimates of compound attrition from failure to meet safety endpoints are as high as 45% in pre...
Understanding the Role of Energy Homeostasis in Diabetes
Introduction
The prevalence of diabetes and obesity has been on the rise for several decades and research has demonstrated that other parts of the body, including the cardiovascular system and kidneys, can be affected by diabetes. The key to understanding the relationship between diabetes and the...
Stool-Based Biomarkers to Differentiate Between IBD and IBS
What are IBD and IBS?
Inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) are two different gastrointestinal tract issues affecting millions of people every day. Although there is some overlap between symptoms of IBD and IBS, differences still remain in regards to pathologies, risks...
Early Detection of Diabetic Kidney Disease with Biomarkers
Introduction
Over one third of diabetics will develop diabetic kidney disease (DKD) in their lifetime1. Despite the large amount of diabetics suffering from DKD, current methods for measuring and tracking kidney function may not be specific enough for diabetic systems2,3.
Part III of The Common ...
The Changing Roles of Bone Remodeling Biomarkers
Introduction
Bones are traditionally known for their support, protection and movement properties, as well as their role in the processes of mineral balance and blood cell production. Research supports that bones do more than they were originally recognized for. Previous research investigating osteo...
Class IA PI3K Inhibitor Cancer Therapies
Date: August 16, 2016
Author: Andrea Tarbet, Product Marketing Associate at ALPCO
Bruton’s tyrosine kinase (BTK) inhibitors are not the only kinase inhibitors to enter the fight against B cell cancers. Since there are numerous subtypes of Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL), p...
PI3K Delta Signaling in Rheumatoid Arthritis
Date: September 6, 2016
Author: Andrea Tarbet, Product Marketing Associate at ALPCO
Signaling pathways dictate the differentiation, activation, and functions of immune cells. Even the slightest problem in one cell signaling pathway can transform the immune system and turn it against the body,...
Regulating Endocrine Disrupting Chemicals in Consumer Products
Date: September 27, 2016
Author: Andrea Tarbet, Product Marketing Associate at ALPCO
From cosmetics to water bottles, endocrine disrupting chemicals (EDCs) have surfaced in our everyday lives. EDCs are compounds that can interfere with the endocrine system’s ability to help an organism develop...
Endocrine Disrupting Chemicals and Biomarkers
Introduction
Humans and the environment are exposed to numerous chemicals every day1. Each year, about 2,000 new chemicals are manufactured in the U.S.2. Research findings over the years have shown how some chemicals known as endocrine disrupting chemicals (EDCs) can interact with the endocrine sys...
[Infographic] Alternative NAFLD and NASH Screening Methods
Download our infographic to understand the prevalence of NAFLD and NASH, as well as how biomarkers can serve as alternative NAFLD and NASH screening methods.
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Estimated Global Prevalence of NAFLD
Research confirms that nonalcoholic fatty liver disease (NAFLD) has an es...