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Responsibility
ALPCO’s Diabetes Research Travel GrantALPCO strives to provide scientists and healthcare professionals with robust tools for their research and clinical diagnostic endeavors. We understand that championing extraordinary discoveries requires extraordinary efforts, and support. We are proud to continu...
ELISA Instrumentation
Automate ELISA Testing to Improve Performance and Productivity Shifting from manual ELISA processing to automation helps reduce variability and improve analytical performance. ALPCO offers automation to optimize workflow, capacity, and productivity.DYNEX DS2® 2-Plate ELISA Processing SystemCompact....
Tips & Tricks
The Enzyme-Linked Immunosorbent Assay (ELISA) is a proven sensitive method for detecting and quantifying specific biomarkers in a wide range of clinical and research samples. The accuracy and precision of ELISAs can be affected by many factors, including pipetting, washing, and sample-handling techn...
The Relationship Between Glucagon and Energy Homeostasis
Glucagon is a gut hormone generated as a result of post translational modifications during proglucagon processing in the pancreas1,2,3. Research has demonstrated that glucagon has many physiological functions1,4. Understanding the role of glucagon in energy homeostasis has become important to many d...
Featured Biomarkers from A to Z
This handout briefly describes the role of several important hormones measured in research.
Early Detection of Diabetic Kidney Disease with Biomarkers
Introduction Over one third of diabetics will develop diabetic kidney disease (DKD) in their lifetime1. Despite the large amount of diabetics suffering from DKD, current methods for measuring and tracking kidney function may not be specific enough for diabetic systems2,3. Part III of The Common ...
Celebrating Diabetes Research
In honor of scientists and researchers in the field of diabetes, we've compiled a partial list of their 2023 published work. These publications aren't just studies; they're milestones on the path to a healthier future, made possible by their dedication.  What makes this list so ...
Heart Disease Biomarkers in Diabetes Research
Introduction Cardiovascular disease (CVD) encompasses a constellation of diseases related to the heart and circulatory system. Despite efforts to understand and combat CVD complications from diabetes, 65% of diabetics will pass away from cardiovascular issues1. Part 2 of The Common Denominator eBoo...
Bone Metabolism: The Cycle of Bone Growth and Resorption
Bone metabolism is a continual cycle of bone growth and resorption that is carefully orchestrated by the dynamic relationship between osteoclasts, osteoblasts and an array of hormonal and regulatory influences. The relative levels of these signaling molecules dictate whether healthy, balanced bo...
The Generation and Function of Active GLP-1
The Generation and Function of Active GLP-1 Active glucagon-like peptide-1 (GLP-1) is a member of the incretin hormone family and is generated as a result of post translational modifications during proglucagon processing1,2. Active GLP-1 plays a key role in the incretin effect and is vital for main...
Incretins GIP and GLP-1 in Diabetes and Obesity
800 million people worldwide struggle with obesity, a disease which will cost over $1 trillion in medical consequences by 2025.  The CDC reports that severe obesity leads to life-altering and often life-threatening conditions like heart disease, stroke, type 2 diabetes, and certain cancers. Wha...
The Role of IgE and IgG in Allergy Testing
Cases of food and environmental allergies have been increasing over the last decade. While conservative estimates suggest IgE-mediated allergy affects 6-8% of children and 2-3% of adults, some estimates are as high as 30%.3, 2 Symptoms can range from mild to severe and include itching, hives...
Insulin Resistance: Root Causes, Detection, and Prevention
The Diabetes Pandemic According to the U.S. Centers for Disease Control (CDC) and the World Health Organization, more than 34 million Americans and 422 million people worldwide have diabetes.1,2 90 to 95% of people with diabetes have type 2.1 The National Institute of Diabetes and Digestive and K...
The Impact of Adiponectin in NAFLD and NASH Research
Date: March 7, 2017 Lately, nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) have been widely discussed in both the clinical and research communities. Some of the focus has been related to alternative research methods that can improve diagnostic and monitoring meth...
Winter 2022 Diabetes Research Travel Grant Recipient
FOR IMMEDIATE RELEASE – ALPCO’s Winter 2022 Diabetes Research Travel Grant has been awarded to Anoop Arunagiri, PhD, a Research Investigator at the University of Michigan. Dr. Arunagiri’s research is centered on studying proinsulin misfolding in pancreatic beta cells, and delineating the events and...
Stool-Based Biomarkers to Differentiate Between IBD and IBS
What are IBD and IBS? Inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) are two different gastrointestinal tract issues affecting millions of people every day. Although there is some overlap between symptoms of IBD and IBS, differences still remain in regards to pathologies, risks...
Immunoassays for Intact and Total Proinsulin
ALPCO is pleased to announce the availability of two new immunoassays, the Intact Proinsulin ELISA and the Total Proinsulin ELISA.  Proinsulin is a precursor molecule produced by pancreatic ß-cells, primarily in response to glucose, that is cleaved equally into insulin and c-peptide. Elevated le...
Marlena Holter Named ALPCO’s Winter 2020 Diabetes Research Travel Grant Recipient
Salem, NH, April 14, 2020 FOR IMMEDIATE RELEASE – Today ALPCO announced Marlena Holter from Cornell University, College of Veterinary Medicine as the latest recipient of its Diabetes Research Travel Grant. Ms. Holter is a DVM/PhD candidate in the Biomedical and Biological Sciences Program researc...
Diabetes and Obesity
Diabetes and Obesity Learning Library! As a leading provider of testing solutions for the diabetes and obesity research community, we support scientists’ efforts to gain a greater understanding of these conditions. With no cure for type 1 or type 2 diabetes and a lack of effective obesity treatment...
Understanding the Role of Energy Homeostasis in Diabetes
Introduction The prevalence of diabetes and obesity has been on the rise for several decades and research has demonstrated that other parts of the body, including the cardiovascular system and kidneys, can be affected by diabetes. The key to understanding the relationship between diabetes and the...
Product Data: Total Proinsulin Chemiluminescence ELISA
ALPCO’s Total Proinsulin Chemiluminescence ELISA offers excellent sensitivity and the greatest dynamic range on the market. 
Physiological Actions of Natriuretic Peptides
Introduction Humans have at least 50 discovered hormones managing vital biological functions in the body. These hormones are produced by the body’s organs and glands. Natriuretic peptides (NPs) are structurally related hormones synthesized and released from the heart, including atrial natriuretic p...
Choosing the Relevant GLP-1 Species to Study
  A better understanding of incretins has led to tremendous therapeutic advances in the field of type 2 diabetes1. These hormones are released from the gut in response to food ingestion and lead to the stimulation of pancreatic β-cells which then release insulin in a glucose-concentration de...

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