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Drug-Induced Organ Injury
Toxicological side effects are a common obstacle in drug development pipelines and often manifest in site-specific damage to vital organs, including the liver, kidney and heart. Estimates of compound attrition from failure to meet safety endpoints are as high as 45% in preclinical models and 40% for Phase I clinical trials.1
Now more than ever, labs engaged in comp...
Bone metabolism is a continual cycle of bone growth and resorption that is carefully orchestrated by the dynamic relationship between osteoclasts, osteoblasts and an array of hormonal and regulatory influences. The relative levels of these signaling molecules dictate whether healthy, balanced bone metabolism ensues. Disturbances to this delicate equilibrium where resorption is greater than ...
Understanding Vitamin D Metabolism & Function
Vitamin D is a steroid hormone involved in the intestinal absorption of calcium and the regulation of calcium homeostasis, bone differentiation and immune response. The term "vitamin D" refers to several different forms of this vitamin.
There are two major types of vitamin D:
Vitamin D2 (ergocalciferol) – which is synthesized by plants ...
The Growth Hormone/IGF axis consists of IGF-1, IGF-2 and several high and low affinity IGF Binding Proteins (IGFBP). The whole system is tightly regulated by a feedback loop involving Growth Hormone (GH) secreted by the pituitary, and GH production and secretion controlled by Growth Hormone Releasing Hormone (GHRH) at the hypothalamus.
Insulin-like Growth Factors & Binding Pr...
Datasheet: Complement System Immunoassays
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The complement system is essential to innate immunity which protects from chronic, autoimmune, and infectious disease. There are three distinct pathways of complement activation: classical, lectin/MBL, and alternative. Each leads to the generation of the same set of effector molecules which help eliminate infections and path...
Dr. Jörgen Wieslander from our partner, Euro Diagnostica, discusses functional assessment of all three pathways of the complement system.
https://www.youtube.com/watch?v=afJwUGoN99M
