Active GLP-1 (7-36) amide Chemiluminescence ELISA

$601.00
Catalog
80-GLP1A-CH01

The STELLUX® Chemi Active GLP-1 (7-36) amide ELISA is intended for the quantitative determination of active GLP- 1 (7-36) amide in human, mouse, and rat EDTA plasma samples collected in the presence of DPP-4 inhibitor.

  • Sample Volume: 25 µL
  • Analytical Sensitivity: 0.15 pM
  • Functional Sensitivity: 0.45 pM 
  • Specificity: 100% for GLP-1 (7-36 amide); Non-detect for other forms
Research Use Only. Not for Use in Diagnostic Procedures.
Species
Human, Mouse, Rat
Regulatory Status
Research Use Only. Not for Use in Diagnostic Procedures.
Product Distribution
Available Worldwide
Range
0.45 - 151.6 pM (1.5 - 500 pg/mL)
Sensitivity
0.15 pM (0.49 pg/mL)
Sizes
96 Wells
Sample Types
EDTA Plasma
Inc Time Hour
2
Inc Time Minute
52
Inc Time Overnight
No
Inc Time See Protocol
No
Sample Size
25
Detection
Chemiluminescence

Glucagon-like peptide-1 (GLP-1) is an extensively well-characterized incretin hormone which regulates both insulin and glucagon secretion. GLP-1 is a highly sought after therapeutic target due to its beneficial effects on glucose homeostasis, particularly through regulation of beta cell mass, function, and viability. GLP-1 is produced in intestinal L-cells in response to food and is well conserved across species. GLP-1 is derived from the cleavage of proglucagon to generate a 1-37 amino acid peptide. Fasting reduces circulating levels of GLP-1. GLP-1 has many physiological effects on the body. Diabetes and obesity scientists have been using two main  GLP-1 research approaches: DPP-4 inhibition and GLP-1 analogs. DPP-4 can inactivate GLP-1 to its forms of GLP-1 (9-36 amide) and GLP-1 (9-37). By inhibiting DPP-4, scientists hope that GLP-1 can continue to influence insulin secretion and restore balance to energy homeostasis. The goal of developing GLP-1 analogs is to engineer a better GLP-1 molecule that has a longer half-life, thus providing longer influences over insulin secretion.

Active GLP-1 (7-36) amide Chemiluminescence ELISA

80-GLP1A-CH01

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