The NGAL ELISA (Lipocalin) is for the determination of NGAL (neutrophil gelatinase-associated lipocalin) in human serum, plasma, tissue extracts or culture media. For research use only. Not for use in diagnostic procedures.
NGAL is a biomarker of kidney tubular damage and
a biological response to the damage process which
is distinctly separated from loss of kidney function
called Acute Kidney Injury (AKI)1. As damage often
precedes loss of function renal expression of NGAL
increases dramatically in a variety of causes and
NGAL is released into both urine and plasma. Accordingly, renal disorders with presence of acute tubular damage are associated with raised urinary and plasma
NGAL levels. Urinary NGAL serves as an early marker
of acute kidney injury after cardiopulmonary bypass
surgery2,3 and both urinary and plasma NGAL levels
provide an early indication of acute renal injury in
unselected patients in intensive care4. Raised urinary
and plasma levels of NGAL have also been observed
in patients with chronic kidney diseases5, and persistently raised urinary levels after renal transplantation
are associated with poor graft function6.
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