Mouse/Rat Vanin-1 ELISA
$804.00
Catalog
04-BI-VAN1MR
The Mouse / Rat Vanin-1 ELISA is a quantitative immunoassay for the determination of mouse or rat Vanin-1 in serum, plasma or urine samples. Vanin-1 (VAN1 / VNN1) is a GPI-anchored glycoprotein of 513 amino acids. The ectoenzyme catalyzes the hydrolysis of pantetheine to pantothenic acid (vitamin B5) and cysteamine, enabling regulation of oxidative stress and inflammation. Research Use Only. Not for Use in Diagnostic Procedures.
Species
Mouse, Rat
Regulatory Status
Research Use Only. Not for Use in Diagnostic Procedures.
Product Distribution
Available in North America Only
Range
6.25-200 pmol/l
Sensitivity
LLOQ: 6.25 pmol/l
Sizes
96 Wells
Sample Types
Plasma, Serum, Urine
Inc Time Hour
4
Inc Time Minute
30
Inc Time Overnight
No
Inc Time See Protocol
No
Sample Size
5
Detection
Colorimetric
Vanin- (VAN1) is a GPI-anchored glycoprotein of 513 amino acids consisting of a base domain and an
enzymatic nitrilase domain (Boersma et al., 2014). The ectoenzyme catalyzes the hydrolysis of pantetheine to
pantothenic acid (vitamin B5) and cyteamine and thus, is involved in the regulation of oxidative stress and
inflammation (Maras et al., 1999). Vanin-1 has a broad tissue expression with the highest levels being observed in kidney tubular epithelial cells (Pitari et al., 2000). The GPI anchor of Vanin-1 can be cleaved by a yet unknown
mechanism, resulting in Vanin-1 being shed into the extracellular space.