The LRG (leucine-rich alpha-2-glycoprotein) ELISA is a sandwich enzyme immunoassay for the quantitative determination of LRG in human serum and plasma samples. Research Use Only. Not for Use in Diagnostic Procedures.
Research Use Only. Not for Use in Diagnostic Procedures.
Product Distribution
Available in North America Only
Range
0 - 200 pg/ml
Sensitivity
0.5 ng/ml
Sizes
96 Wells
Sample Types
Plasma, Serum
Inc Time Hour
3
Inc Time Minute
30
Inc Time Overnight
No
Inc Time See Protocol
No
Sample Size
5 μl
Detection
Colorimetric
LRG (leucine-rich alpha-2-glycoprotein) is a glycoprotein with a molecular mass of 38.2 kDa. It is encoded by the human gene LRG-1 which is mapped on chromosome 19 at the cytogenetic band 19p13.3. The protein LRG (or also named LRG1) runs at approximately 50 kDa under reducing conditions, as it contains a carbohydrate content of 23% (1). LRG is the founding member of the family of leucine-rich repeat proteins (2). The mature protein consists of 312 amino acids, from Val36 to Gln347, with a leucine content of 66 amino acids. LRG is folded to eight leucine-rich repeat (LRR) domains of 22 amino acid length, and a C-terminal LRRCT domain with 49 amino acid length (3). Human LRG shows 62.5% sequence identity with mouse LRG, and 60.7% with rat LRG. LRG binds to the TGFβ accessory receptor endoglin, and in the presence of TGFβ1 this leads to the induction of the TβRII-ALK1-Smad1/5/8 signaling pathway (4). TGFβ1 therefore promotes binding of LRG to the proangiogenic ALK1 but inhibits the interaction with angiostatic ALK5.
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