IGFBP-2 ELISA
The IGFBP-2 ELISA is for the quantitative determination of IGFBP-2 in human serum, plasma, saliva, CSF, amniotic fluid, breast milk, and cell culture medium. For Research Use only. Not For In Vitro Diagnostic Use.
Dynamic range
2-80 ng/mL
Sensitivity
0.2 ng/mL
Sample size
15 µL
Insulin-like growth factors (IGFs) regulate the proliferation, differentation, apoptose, cell adhesion and metabolism in various tissues and cell types. The IGF-I, which is produced mainly in liver under the influence of growth hormone (GH), regulates as hormone the linear growth of the bones and the process of sexual maturity, while IGF-II is mainly a growth factor of fetal tissue. The biological actions of IGF over the IGF-Type-I receptor are modulated variably through the IGF binding proteins (IGFBP-1 to-6). IGFBP-2 is, after IGFBP-3, the second most frequent IGFBP in the human blood. IGFs, especially tumor typical pro-IGFforms and hormones regulate the expression of IGFBP-2, GH effect is thereby inhibiting. At cellular level IGFBP-2 seems to stimulate the proliferation and dissemination of solid tumors via an IGF-independent mechanism.
