The Complement Factor P Quantitative ELISA is for the quantitative determination of the function of Factor P in human serum or EDTA plasma. For Research Use Only. Not for Use in Diagnostic Procedures.
Research Use Only. Not for Use in Diagnostic Procedures.
Product Distribution
Available in North America Only
Range
0-200 ng/ml
Sensitivity
12.5 ng/ml
Sizes
96 Wells
Sample Types
EDTA Plasma, Serum
Inc Time Hour
2 hr
Inc Time Overnight
No
Inc Time See Protocol
No
Sample Size
100
Detection
Colorimetric
The Factor P Quantitative Assay is a sandwich ELISA for quantifying human Factor P
in serum or EDTA plasma. The assay is based on immobilized antibody in a 96-well plate, which captures Factor P present in samples incubated in the plates. The bound Factor P is detected with a secondary antibody labelled with HRP. The HRP subsequently catalyzes a cleavage of the substrate that induces a color change correlating with the concentration of Factor P in the sample.
Factor P (Complement P, Properdin, FP) is a positive regulator and an initiator of the
alternative pathway (AP) for complement activation. It binds surface-bound C3 and C5
convertases and stabilizes them to amplify the activation cascade1. Factor P binding
increases the half-life of the convertase complex approximately 10-fold2. It is suggested,
however debated, that Factor P also can initiate complement activation by binding for
example cell surfaces or certain biological substrates, recruiting C3b or C3(H2O) and Factor
B and thus initiate the AP pathway1,3. Factor P opposes the negative regulation of Factor H
that enhances the dissociation of C3b and Bb and mediates Factor I cleavage of C3b to the
inactive iC3b3. Please see instructions for use for more information.
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