The Beta-4 Thymosin ELISA is for the quantitative determination of Thymosin ß4 in Serum and thymus extract. Research Use Only. Not for Use in Diagnostic Procedures.
Research Use Only. Not for Use in Diagnostic Procedures.
Product Distribution
Available in North America Only
Range
0.16 - 10 µg/mL
Sensitivity
0.1 µg/mL
Sizes
96 Wells
Sample Types
Serum, Tissue Culture
Inc Time Hour
2
Inc Time Minute
20
Inc Time Overnight
No
Inc Time See Protocol
No
Sample Size
50
Detection
Colorimetric
The beta-thymosins are a family of highly conserved polar 5kDa peptides originally
thought to be thymus hormones. Further studies demonstrated that beta-thymosins
are ubiquitous; they have been found in a variety of tissues and cell lines. The highest concentrations have been detected in spleen, thymus, lung, and peritoneal macrophages.
Thymosin β4
binds monomeric actin in a 1:1 complex acting as an actin buffer, preventing polymerisation into actin filaments but supplying a pool of actin monomers
when needed by the cell. Changes in the expression of thymosin β4
appear to be
related to the differentiation of cells. Thymosin β4
is detected outside of cells in blood
plasma and wound fluid. Several biological effects are attributed to thymosin β4
, like
induction of metallo-proteinases, chemotaxis, angiogenesis and inhibition of inflammation as well as inhibition of bone marrow stem cell proliferation.
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