The Anti-Jo-1 ELISA is a solid phase enzyme immunoassay with recombinant human histidyltRNA-synthetase (HRS) for the quantitative and qualitative detection of antibodies against Jo-1 in human serum. Human sera with anti-Jo-1 antibodies solely recognize HRS of higher eukaryotes and react with highest affinity to the human enzyme. For Research use only. Not for use in diagnostic procedures.
Antibodies against Jo-1 are directed against the reactive site of histidyl-tRNA-synthetase (HRS)
which is a cytoplasmic enzyme belonging to the group of aminoacyl transferases. These are
responsible for the linking of the respective amino acid (for HRS it is histidine) to its cognate
transfer RNA. HRS is present in the cell as homodimer, its identical subunits of approximately
50 kDa are each bound to tRNA. Measuring antibodies against Jo-1 is useful for researching
polymyositis or dermatomyositis.
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