Bone metabolism is a continual, cyclic interplay of bone growth and resorption. The dynamic relationship between osteoclasts, osteoblasts and an array of hormonal and regulatory influences carefully orchestrates this process. The relative levels of these signaling molecules dictate whether healthy, balanced bone metabolism ensues. Disturbances to this delicate equilibrium, where reabsorption is greater than growth, can weaken the skeletal architecture and put one at risk for the development of chronic and debilitating diseases, such as osteoporosis.

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