The Secretory IgA ELISA is intended for the quantitative determination of secretory immunoglobulin A (sIgA) in human stool. For Research Use Only. Not for Use in Diagnostic Procedures. This kit is a replacement for catalog# 30-SECHU-E01.
Secretory IgA consists of two immunoglobulin A molecules connected to each other by a J protein (joining) and a secretory component. The secretory component is synthesized by the epithelial cells of the mucous membranes of the gastrointestinal, respiratory, and urogenital tracts, as well as in the salivary, lacrimal, and mammary glands. The plasma cells in the subendothelial space of the mucous membranes secrete a complex of two IgA molecules linked via the J protein. This complex then binds to the secretory component that sits on the surface of the epithelial cell. After binding, the sIgA is transported through the epithelial cell and excreted at the mucosal surface by exocytosis.
The determination of the secretory IgA (sIgA) provides an initial overview of the functional status of the gut-associated immune system (GALT). Here, the secretion capacity and the degree of stimulation of the plasma cells in the submucosa of the intestine are recorded.
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