The Sclerostin ELISA is intended for the quantitative determination of sclerostin in Human serum, EDTA plasma or heparin plasma.
- Includes controls and standards
- Small sample volume requirement: 20 µL
- Colorimetric Detection
- Excellent precision and reproducibility
- Intra-assay CV 7%
- Inter-assay CV 10%
For Research Use Only. Not for Use in Diagnostic Procedures.
Sclerostin (SOST) is a 22.5 kD secreted glycoprotein produced in osteocytes and is considered a highly specific biomarker for bone. SOST inhibits osteoblast activity via antagonism of the Wnt Signaling pathway and plays a key role in the regulation of bone formation.
SOST levels are of interest in many research fields including bone metabolic diseases, multiple myeloma, chronic kidney disease, type 2 diabetes, and chronic inflammation.