The Relaxin ELISA is for the determination of Relaxin in Plasma, Serum, Urine, Cell Culture, seminal Plasma and Tissue extract. Research Use Only. Not for Use in Diagnostic Procedures.
Relaxin is a peptide hormone with a molecular weight of 6500Da that belongs to
the insulin family. Its main function is the relaxation of smooth musculature. Because
of the increased relaxin levels during ovulation and pregnancy most of the knowledge about its physiological properties is gained in the field of gynecology and
reproductive sciences. Recently, novel sites of relaxin action have been recognised.
In particular, it has been shown that relaxin: (i) promotes dilation of blood vessels
in several organs and tissues, including the uterus, the mammary gland, the lung
and the heart; (ii) has a chronotropic action on the heart; (iii) inhibits the stimulation
of endothelin-1, the most potent vasoconstrictor in heart failure; (iv) inhibits the
release of histamine by mast cells, thus being able to counteract experimental
allergic asthma; (v) depresses aggregation of platelets and their release by megakaryocytes; (vi) influences the secretion of hormones by the pituitary gland; and (vii)
contributes to the regulation of fluid balance. See instructions for use for references.
Species
Human
Regulatory Status
Research Use Only. Not for Use in Diagnostic Procedures.
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