Human Pentraxin3 / TSG-14 ELISA System is a solid-phase sandwich immunoassay (ELISA) capable of measuring human PTX3 levels in plasma and serum free cell culture supernatant. Pentraxins are a superfamily of conserved proteins characterized by the pentraxin domain. C-reactive protein (CRP) and serum amyloid protein (SAP) are recognized as classical short pentraxins, whereas pentraxin3 (PTX3) belongs to the long pentraxins. CRP and SAP are induced in the liver in response to IL-6. In contrast, PTX3 is produced by a variety of tissues and cells, such as vascular endothelial cells, macrophages, and neutrophils, predominantly in response to proinflammatory signals (bacterial products, IL-1, and TNF). PTX3 has also been observed in human atherosclerotic lesions of autopsy samples by immunohistochemistry, in association with macrophage and neutrophils infiltration. This localized expression pattern of PTX3 is believed to be indicative of primary inflammation stimuli, in contrast to CRP which is induced via secondary signals.
Regulatory Status
Research Use Only. Not for Use in Diagnostic Procedures.
1. What percentage of your IgE allergy testing panel consists of molecular allergens rather than allergen extracts? The ALEX2 IgE allergen panel consists of 117 extracts and 183 molecular allergens. This represents the largest panel of molecular allergens on the market, including 50 unique...
Cases of food and environmental allergies have been increasing over the last decade. While conservative estimates suggest IgE-mediated allergy affects 6-8% of children and 2-3% of adults, some estimates are as high as 30%.3, 2 Symptoms can range from mild to severe and include itching, hives,...
Food sensitivity or food intolerance involves a non-allergic response to a food or food additive. In a recent on-line survey conducted in the U.S., 24% of adults aged 18 to 79 reported a food intolerance. While a food allergy is typically mediated by IgE antibodies, adverse reactions to food...
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July 22, 2025 – Salem, NH – NuvinkaDx, a leading innovator in diagnostic solutions, today announced two significant product and regulatory milestones from its operating companies, GeneProof and ALPCO.
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