The Intact Proinsulin ELISA is a quantitative immunoassay for the determination of intact proinsulin in human EDTA plasma, and heparin plasma samples. For Research Use Only. Not for use in diagnostic procedures.
Research Use Only. Not for Use in Diagnostic Procedures.
Product Distribution
Available Worldwide
Range
1.2 - 100 pmol/L
Sensitivity
0.3 pmol/L
Sizes
96 Wells
Sample Types
EDTA Plasma, Heparin Plasma
Inc Time Hour
3
Inc Time Minute
30
Inc Time Overnight
No
Inc Time See Protocol
No
Sample Size
50
Detection
Colorimetric
Proinsulin is a precursor molecule for insulin and is synthesized by the pancreatic β-cells. Under normal circumstances, virtually all proinsulin is cleaved at residues 32-33 and 65-66 to produce insulin during the formation of secretory granules. Some unmodified proinsulin is released into the circulation, though it is believed to have little or no biological activity. Increased concentrations of circulating proinsulin may occur in insulin-resistant syndromes such as type 2 diabetes and in patients with insulinoma. When used in conjunction with a highly specific insulin assay, it may provide useful information on changes in the processing of insulin in such situations.
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