The gastrin RIA is a quantitative radioimmunoassay for the determination of gastrin in human samples. This is a RUO replacement for product 38-KIPEMD302. The antiserum used in this assay detects gastrin-34 and the sulphated forms of gastrin-17.
Gastrin occurs in many different forms in human serum. An amidated C-terminal is essential for the biological activity of the gastrins. Progastrin is cleaved from preprogastrin. It has been shown that progastrin is partially sulphated in the tyrosine residues. The progastrin is enzymatically cleaved to the main circulating forms of biologically active gastrin: gastrin-34 and gastrin-17, which occur in sulphated an non-sulphated forms. Small amount of gastrin-52 (also named component 1), gastrin-14 (mini-gastrin) and even smaller fragments have been detected in serum.
Species
Human
Regulatory Status
Research Use Only. Not for Use in Diagnostic Procedures.
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