The FGF23 (Intact) ELISA is validated for the quantitative determination of human intact FGF23 in plasma (EDTA, citrate, heparin) samples. Serum and other sample types are also compatible with this ELISA.
For Research Use Only. Not for Use in Diagnostic Procedures.
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FGF23 (fibroblast growth factor 23) is a member of the fibroblast growth factor family and controls phosphate and vitamin D homeostasis. The full-length protein comprises 251 amino acids including a 24 amino acid signal peptide. The N-terminal FGF region of FGF23 is separated from the C-terminal region by a proteolytic cleavage site. A fraction of FGF23 is proteolytically processed between arginine179 and serine180 to generate N-terminal and Cterminal fragments. Therefore, the main forms of FGF23 present in human circulation are hormonally intact FGF23 and inactive N-terminal and C-terminal fragments. FGF23 binds to FGF receptor 1c (FGFR1c) with its N-terminal region, while the C-terminal region interacts with the co-receptor α-Klotho to confer high-affinity binding to the receptor. FGFR1c and α-Klotho are expressed in the distal nephron and the parathyroid gland. Co-receptor independent signaling of FGF23 has been described for other FGFRs, which are expressed in a variety of tissues. The main source of FGF23 are osteocytes in the bone.
Species
Human
Regulatory Status
Research Use Only. Not for Use in Diagnostic Procedures.
Product Distribution
Available in North America Only
Range
5.4 – 1600 pg/mL
Sensitivity
5.4 pg/mL
Sizes
96 Wells
Sample Types
Citrate Plasma, EDTA Plasma, Heparin Plasma, See Package Insert, Serum
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