SM is a solid phase enzyme immunoassay with highly purified native Smith antigen (Sm) from human eukaryotic cells (HeLa) for the quantitative and qualitative detection of antibodies against Sm in human serum. Anti-Sm antibodies recognize specific conformational epitopes only accessible on native human Sm.
Research Use Only. Not for Use in Diagnostic Procedures.
The term “Smith antigen“ summarizes core proteins of the U1-snRNP complex. The U1snRNP complex is a part of the splicosomal complex, that facilitates the processing of pre-mRNA to mature mRNA in the nucleus. It is a small nuclear ribonucleoprotein particle composed of uridine-rich (thus U) small nuclear RNA and a set of proteins: the 70 kDa U1specific protein plus proteins A and C (all formerly summarized as RNPs) and the Sm antigen which comprises eight proteins (B,/B`, D1, D2, D3, E, F, and G). Because of its protein components Sm and RNPs the complex has been often named Sm/RNP complex.
1. What percentage of your IgE allergy testing panel consists of molecular allergens rather than allergen extracts? The ALEX2 IgE allergen panel consists of 117 extracts and 183 molecular allergens. This represents the largest panel of molecular allergens on the market, including 50 unique...
Cases of food and environmental allergies have been increasing over the last decade. While conservative estimates suggest IgE-mediated allergy affects 6-8% of children and 2-3% of adults, some estimates are as high as 30%.3, 2 Symptoms can range from mild to severe and include itching, hives,...
Food sensitivity or food intolerance involves a non-allergic response to a food or food additive. In a recent on-line survey conducted in the U.S., 24% of adults aged 18 to 79 reported a food intolerance. While a food allergy is typically mediated by IgE antibodies, adverse reactions to food...
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July 22, 2025 – Salem, NH – NuvinkaDx, a leading innovator in diagnostic solutions, today announced two significant product and regulatory milestones from its operating companies, GeneProof and ALPCO.
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