This ELISA is intended for the quantitative determination of 1,25-dihydroxyvitamin D in serum and plasma. For research use only. Not for use in diagnostic procedures.
Research Use Only. Not for Use in Diagnostic Procedures.
Product Distribution
Available in North America Only
Range
5.1 - 200 pg/mL
Sensitivity
4.8 pg/mL
Sizes
96 Wells
Sample Types
Plasma, Serum
Inc Time Overnight
No
Inc Time See Protocol
No
Sample Size
500
Detection
Colorimetric
Vitamin D is either produced in the skin (under the influence of UV light) or taken up from nourishment. The storage type of vitamin D, namely 25-hydroxyvitamin D, is formed in the liver. The hormone 1,25-dihydroxyvitamin D (D hormone) is formed in a second hydroxylation step in the kidney. The responsible enzyme, the kidney 1α-hydroxylase, is subjected to a rigid control through hormones (especially parathyroid hormone) and its activity is influenced by the serum concentrations of calcium and phosphate. The serum concentration of 1,25-dihydroxyvitamin D normally re-adjusts itself to the demands of metabolism. The reason for a non-physiological deficiency of 1,25-dihydroxyvitamin D can be found in metabolic disturbances, caused either by genetic defects of the enzyme 1α-hydroxylase (rare) or kidney malfunctions (more common). Even a slightly impaired kidney function can lead to a decrease of the 1,25-dihydroxyvitamin D concentration.
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