Neurological disorders can be caused by a variety of systematic diseases, toxic exposures, medications, infections and hereditary disorders.(1) Studies have linked the presence of high anti-ganglioside titers to several neuropathies, Additionally, correlations have been drawn between the severity of the disorder and the isotype detected. IgG antibodies have been strongly associated with acute conditions, while IgM antibodies tend to be present in chronic diseases. Many of these neurological disorders exhibit similar symptoms involving sensory loss and distal pain, numbness, tingling and weakness, causing them to be difficult to dissociate. An increasing level of research indicates immunological tests for ganglioside antibodies plays an important role in the diagnosis and management of neuromuscular diseases.(2)
1. Azhary, Hend. et al. Peripheral Neuopathy: Differential Diagnosis and Management. American Family Physician. Apr 2010; Vol 81:887-892.
2. Winner, John. Antibodies and clinical neurological syndromes. The Biomedical Scientist. Jul 2006; 622-624.