Therapeutic Drug Monitoring in Autoimmune and Inflammatory Arthritis
TNF-α blocker biologics can be used to tr eat multiple forms of autoimmune and inflammatory arthritis including:
- Rheumatoid arthritis (RA)
- Psoriatic arthritis (PA)
- Ankylosing spondylitis (AS)
- Plaque psoriasis (PP)
Therapeutic drug monitoring (TDM) of TNF-α blocker drug levels, anti-drug antibody (ADA) levels, and inflammatory markers can be used to investigate the pharmacokinetic-pharmacodynamic (PK-PD) profiles of these diseases. TDM assays can measure both the drug and ADA levels of the TNF-α blockers adalimumab, infliximab, golimumab, and etanercept.