Therapeutic Drug Monitoring in Autoimmune and Inflammatory Arthritis

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TNF-α blocker biologics can be used to tr eat multiple forms of autoimmune and inflammatory arthritis including:

  • Rheumatoid arthritis (RA)
  • Psoriatic arthritis (PA)
  • Ankylosing spondylitis (AS)
  • Plaque psoriasis (PP)

Therapeutic drug monitoring (TDM) of TNF-α blocker drug levels, anti-drug antibody (ADA) levels, and inflammatory markers can be used to investigate the pharmacokinetic-pharmacodynamic (PK-PD) profiles of these diseases. TDM assays can measure both the drug and ADA levels of the TNF-α blockers adalimumab, infliximab, golimumab, and etanercept.