The RANK/sRANKL/OPG System

RANK sRANKL OPG System

Bone metabolism is a continual, cyclic interplay of bone growth and resorption that is carefully orchestrated by the dynamic relationship between osteoclasts, osteoblasts and an array of hormonal and regulatory influences. The relative levels of these signaling molecules dictate whether healthy, balanced bone metabolism ensues. One of the regulatory systems used to keep bone metabolism balanced is the RANKL/RANK/OPG system.