Liver Lipid Metabolism: De Novo Lipogenesis and Metabolic Syndrome
De novo lipogenesis (DNL) is the process by which the liver synthesizes fatty acids by breaking down glucose. Research has shown that both glucose concentration and insulin signaling promote DNL through the activation of the transcription factors: SREP1c and chREBP. Increased lipid levels and glucagon inhibit DNL to maintain lipid homeostasis.
Download our Liver Lipid Metabolism brochure to understand the relationship between de novo lipogenesis and metabolic syndrome.