Alpco immunoassay

DKK-1 (Dickkopf-1) ELISA

ALPCO Catalog Number: 04-BI-20412

DKK-1 (Dickkopf-1) ELISA

For Research Use Only This item appears in: Bone Metabolism  Format:  ELISA / EIA  Sample Type: serum  Sample Size: 15 µl  Size:  96 wells  Range:  3.125 - 50 pmol/L  Sensitivity:  0.38 pmol/l  Incubation Time:  Overnight  Protocol:    Download Protocol   (149 KB) International Distribution:  Only available in North America  Price:   Related Products:

The DKK-1 ELISA is an enzyme immunoassay intended for the quantitative determination of human DKK-1 in Serum. Dickkopf-1 (DKK-1) is a 28,672 Da secreted protein that acts as soluble inhibitor of the wnt signalling pathway. This pathway involves lipid modied glycoproteins that activate cell surface receptor-mediated signal transduction to regulate cellular activities such as cell fate, proliferation, migration, polarity and gene expression. DKK-1 is also involved in the regulation of bone metabolism as it effects osteoblast differentiation and in the regulation of tumorigenic activity. Possible indications include osteoarthritis, osteoporosis, colon carcinomas, multiple myeloma and breast cancer metastasis to bone.

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dickkopf WNT bone osteoblast