Alpco assay

ADMA (Mouse/Rat) ELISA

ALPCO Catalog Number: 30-3001

ADMA (Mouse/Rat) ELISA

For Research Use Only  Format:  ELISA / EIA  Sample Type: serum, EDTA plasma  Sample Size: 100 µl  Size:  96 wells  Range:  0.1 - 3 µmol/l  Sensitivity:  0.05 µmol/l  Incubation Time:  Overnight  Host:   0    Form:   0    Clone Isotype:   0    Known Applications:  0  Protocol:    Download Protocol   Error 417: The protocol was not found for this product. Please tell the webmaster about this problem. International Distribution:  Only available in North America  Price:   Related Products:

Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of NO-synthase. It is
formed during proteolysis of methylated proteins and removed by renal excretion or
metabolic degradation by the enzyme dimethylarginine dimethylaminohydrolase
(DDAH). Several cell types, including human endothelial and tubular cells, are capable
of synthesizing and metabolizing ADMA. Elevated ADMA concentrations in the blood
are found in numerous diseases associated with endothelial dysfunction. For example, elevated ADMA levels in the blood of individuals on dialysis correlate significantly with the degree of arteriosclerosis and cardiovascular risk. Furthermore, elevated ADMA levels are found in individuals with hypercholesterolemia, hypertension, arteriosclerosis, chronic renal failure, and chronic heart failure, and are associated with restrictions in endothelial vasodilatation.

Tags

NO, nitric oxide, ADMA, asymmetric dimethylarginine, asymetric, di-methylarginine