Alpco ELISA

ADMA (Asymmetric Dimethylarginine) ELISA

ALPCO Catalog Number: 30-7828

ADMA (Asymmetric Dimethylarginine) ELISA

For Research Use Only  Format:  ELISA / EIA  Sample Type: serum, plasma, EDTA plasma, citrate plasma  Sample Size: 50 µl  Size:  96 wells  Range:  0.1 - 2.0 µmol/l  Sensitivity:  0.05 µmol/l  Incubation Time:  Overnight  Protocol:    Download Protocol   (146 KB) International Distribution:  Only available in North America  Price:   Related Products:

Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of NO synthase. It is formed during proteolysis of methylated proteins and removed by renal excretion or metabolic degradation by the enzyme dimethylarginine dimethylaminohydrolase (DDAH). Several celltypes, including human endothelial and tubular cells are capable of synthesizing and metabolizing ADMA. Elevated ADMA concentrations in the blood are found in numerous diseases associated with endothelial dysfunction. For example, elevated ADMA levels in blood of dialysis patients correlate significantly with the degree of arteriosclerosis and cardiovascular risk. Furthermore, elevated ADMA levels are found in patients with hypercholesterolemia, hypertension, arteriosclerosis, chronic renal failure and chronic heart failure, and are associated with restrictions in endothelial vasodilatation.

Tags

nitric oxide, ADMA, asymmetric dimethylarginine, asymetric, assymmetric, assymetric