Alpco assay

11-Desoxycortisol RIA

ALPCO Catalog Number: 38-DESHU-R96
11-Desoxycortisol RIA
  For Research Use Only For Research Use Only
 Format:  Radioimmunoassay
 Sample Type: serum
 Sample Size: 25 µl
 Size:  96 wells
 Range:  0.3 - 65 ng/ml
 Sensitivity:  0.04 ng/ml
 Incubation Time:  2 Hour 30 Min
 Host:   0  
 Form:   0  
 Clone Isotype:   0  
 Known Applications:  0
 Protocol:   PDF Format Download Protocol   (213 KB)
International Distribution:  Only available in North America
 Price:  Buy Now
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The 11-Desoxycortisol (Compound S) is an intermediate steroid in the biosynthesis of glucocorticoids. As a precusor of cortisol, it comes from 17-hydroxyprogesterone after action of the 11-beta-hydroxylase. This parameter is interesting for the study of surrenal enzymatic deficiency in 11-beta-hydroxylase, which is responsible for congenital surrenal hyperplasia in children and hyperandrogenics in adult women. Under hypothalamic-pituitary control via the Adrenocorticotropic hormone (ACTH), the secretion of 11-Desoxycortisol follows a nycthemeral variation: it reaches a maximum in the morning (around 8 a.m.) and a minimum during the night (between 0 to 4 a.m.)

The measure of 11-Desoxycortisol can be performed in serum using immunological competition methods (RIA).

Tags

cortisol, deoxycortisol, desocycortisol, ACTH, 11-DOC, DOC, Compound S, Compound-s