For Research Use Only

 

Summary:

Physiological function of 25OH Vitamin D3 25-Hydroxyvitamin D3 (25OHD3) is the trivial name of 9, 10-secocholesta-5, 7, 10(19)-triene-3beta, 25-diol. This secosteroid is produced in the liver by 25-hydroxylation of cholecalciferol or Vitamin D3. 25OHD3 is a precursor for other Vitamin D metabolites and has only a limited biological activity in itself. The most active derivative is 1alpha,25-Hydroxyvitamin D3, produced in the kidney (or placenta) by 1alpha-hydroxylation of 25-OH D3. This hormonally regulated steroid stimulates the intestinal absorption of both calcium and phosphorus. It also stimulates bone resorption and mineralization thereby preventing the development of rickets or osteomalacia. This Vitamin D hormone might also be active in other tissues responsible for calcium transport (placenta, kidney, mammary gland, ...) and endocrine glands (beta-cells, parathyroid glands, ...). 25-hydroxyvitamin D3 is a main precursor for the metabolites.

The 25-OH Vitamin D3 Radioimmunoassay is for the in vitro quantitative measurement of 25OH-Vitamin D3 in human serum and plasma and is for research only.